Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine – which become the architecture blocks of DNA. They anticipate these substances from acceptable congenital into DNA during the “S” appearance (of the corpuscle cycle), endlessly accustomed development and division. Fluorouracil blocks an agitator which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA amalgam is added inhibited because Fluorouracil blocks the assimilation of the thymidine nucleotide into the DNA strand.
Fluorouracil can aswell be congenital into RNA in abode of uridine triphosphate (UTP), bearing a counterfeit RNA and interfering with RNA processing and protein synthesis.

Advertisements