Trandolapril is an ACE inhibitor which is accustomed for use abandoned and in aggregate with added agents in the analysis of hypertension and congestive affection failure. Like added ACE inhibitors, trandolapril inhibits the about-face of angiotensin I, a almost abeyant molecule, to angiotensin II which is the above advocate of vasoconstriction and aggregate amplification induced by the renin-angiotensin system.
Other host enzymes besides that which converts angiotensin I to II may be inhibited as well, which may annual for some of the ancillary furnishings of the ACE inhibitors. Trandolapril was accustomed for use in the United States in 1996 and is accessible in 1, 2 and 4 mg tablets in all-encompassing forms and beneath the barter name Mavik. The archetypal circadian dosage in adults is 2 to 4 mg in one or two disconnected doses which is administered continued term. Trandolapril is aswell accessible in anchored dosage combinations with verapamil (Tarka and generics). Common ancillary furnishings cover dizziness, fatigue, headache, cough, gastrointestinal agitated and derma rash.