Synonym: Butyric acid sodium salt
CAS Number: 156-54-7
Molecular Weight: 110.09
Molecular Formula: C4H7O2•Na
Solubility: Soluble in water (0.1 g/ml), DMSO (<1 mg/ml), ethanol (~5 mg/ml), and PBS pH7.2 (~10 mg/ml). Insoluble in ether.
Melting Point: 250-253° C (lit.)
Application: An HDAC inhibitor and apoptosis inducer
Storage: Store at -20° C
Sodium Butyrate has been appear to could could cause hyperacetylation of histones due to its role as a histone deacetylase (HDAC) inhibitor (IC50 ethics are 0.3, 0.4, 0.3, mM for HDAC1, 2 and 7 respectively). This admixture has been apparent to could could cause consecration of adverse and gene announcement and aswell anticipate corpuscle proliferation. Mechanistic studies advance that the action of Sodium Butyrate is generally advised through Sp1/Sp3-associated HDAC action which leads to transcriptional activation of the p21 gene. Additionally this abettor demonstrates the adeptness to downregulate abundant genes associated with cytokine signaling, specifically, the IFN-γ (interferon γ) pathway.