Diosgenin is a steroid sapogenin and the forerunner for the semisynthesis of progesterone which in about-face was acclimated in aboriginal accumulated articulate contraceptive pills.It is the artefact of hydrolysis by acids, able bases, or enzymes of saponins, extracted from the tubers of Dioscorea agrarian yam, such as the Kokoro. The sugar-free (aglycone), diosgenin is acclimated for the bartering amalgam of cortisone, pregnenolone, progesterone, and added steroid products. Diosgenin aswell causes an inhibition of the advance of fibroblast-like synoviocytes from animal rheumatoid arthritis, with apoptosis consecration associated with cyclooxygenase-2 (COX-2) up-regulation. Celecoxib, a careful COX-2 inhibitor, affronted a ample abatement in diosgenin-induced apoptosis even in the attendance of exogenous prostaglandin E2, admitting interleukin-1β, a COX-2 inducer, acerb added diosgenin-induced apoptosis of these synoviocytes. LD50: Mice 3563mg/kg (i.p.), >8000mg/kg (i.g.); Rats 898.7mg/kg (i.p.) >8000mg/kg (i.g.).