A contempo abstraction approved that administering of lycopene (90 mg/kg physique weight) to streptozotocin-induced hyperglycemic rats acquired a abatement in glucose levels, an access in insulin concentration, a abatement in H2O2 and thiobarbituric acerbic acknowledging substances levels, added absolute antioxidant status, and added antioxidant agitator activities (ie, catalase, superoxide dismutase, glutathione peroxidase) with advance in serum lipid profile. Kuhad et al appear that lycopene at doses of 1, 2, and 4 mg/kg has significant, dose-dependent antidiabetic activity in streptozotocin-induced diabetic rats.In a analytic abstraction investigating the role of lycopene in diabetic patients (N=133), lycopene bargain the accident of diabetic retinopathy.