Daptomycin is an antibacterial abettor of a new chic of antibiotics, the circadian lipopeptides. Daptomycin is a accustomed artefact that has analytic account in the analysis of infections acquired by aerobic Gram-positive bacteria. The in vitro spectrum of action of daptomycin encompasses a lot of clinically accordant Gram-positive pathogenic bacteria. Daptomycin retains authority adjoin antibiotic-resistant Gram-positive bacteria, including isolates aggressive to methicillin, vancomycin, and linezolid.
Daptomycin exhibits rapid, concentration-dependent antibacterial action adjoin Gram-positive bacilli in vitro. This has been approved both by time-kill curves and by MBC/MIC ratios (minimum antibacterial concentration/minimum inhibitory concentration) application borsch concoction methodology. Daptomycin maintained antibacterial action in vitro adjoin anchored appearance S. aureus in apish endocardial vegetations. The analytic acceptation of this is not known.