Cefoperazone sodium is a semi-synthetic 3rd bearing cephalosporin able adjoin a advanced ambit of aerobic and anaerobic gram-positive and gram-negative bacteria. It is a white to anemic chicken apparent powder; acrid in water, methanol; hardly acrid in dehydrated alcohol; baffling in acetone, ethyl acetate, ether. Chemical appellation is [6R-[6a,7b(R’)]]-7-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl] amino](4-hydroxyphenyl) acetyl]amino]-3 -[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo- 5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt.
Cefoperazone sodium is reportedly accordant with cimetidine HCl, clindamycin phosphate, furosemide and heparin sodium, acyclovir sodium, cyclophosphamide, esmolol HCl, famotidine, hydromorphone HCl, magnesium sulfate, and morphine sulfate. It is reportedly adverse with some TPN mixtures, doxapram HCl, gentamicin sulfate, hetastarch, labetolol HCl, meperidine HCl, odansetron HCl, perphenazine, promethazine, and sargostim. Compatibility is abased aloft factors such as pH, concentration, temperature and diluents used. It is appropriate to argue specialized references (e.g., Handbook on Injectable Drugs by Trissel; see bibliography) for added specific information.